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KMID : 0370220210650040284
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Yakhak Hoeji
2021 Volume.65 No. 4 p.284 ~ p.291
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Effect of Spatholobi Caulis Extract in Acute Liver Injury
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Oh Min-Hyuck
Park Hae-Jin
Shin Mi-Rae
Roh Seong-Soo
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Abstract
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This study aimed to examine the protective effect of the water extract from Spatholobi Caulis (SC) on rats withacute liver injury (ALI) induced by thioacetamide (TAA) and its underlying mechanism. ALI was induced byintraperitoneal injection with TAA for 3 days in a row and the rats were administered SC (100 or 200 mg/kg) 1 h 30min prior to the TAA treatment. Myeloperoxidase (MPO) was measured in serum and malondialdehyde (MDA) wasmeasured in serum and liver tissue, as markers related to oxidative stress. Further, inflammation-related proteins andapoptosis proteins were investigated using western blot analysis. SC treatment significantly reduced the levels of MPO andMDA. Further, SC treatment significantly reduces the mitogen-activated protein kinase (MAPK) signaling pathway,including p-JNK, p-ERK, and p-p38, and reduces the expression of pro-inflammatory signaling factors. Furthermore, iteffectively decreased the expression of Bax, Cytochrome C, and Cleaved Caspase-3 in liver tissue. Taken together, SCtreatment alleviate0d the severity of ALI via inhibition of inflammation through both the MAPK pathway and Matrixmetalloproteinase (MMPs)-dependent apoptosis.
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KEYWORD
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Spatholobi Caulis, Thioacetamide, Acute liver injury
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